the involvement of l-type voltage-operated calcium channels in the vascular effect of quercetin in male rats

in this study, the possible involvement of l-type voltage-operated calcium channels in the vasorelaxant effect of the flavonoid quercetin was investigated, using the isolated aortic rings from normal male rats. addition of quercetin (0.1 µm-1 mm) caused a significant dose-dependent relaxation of noradrenaline (na)- and kcl-preconstricted rings and nifedipine attenuated this response, especially for noradrenaline (p<0.05). it is concluded that the flavonoid quercetin produces a potent relaxation of the rat aorta and blockade of voltage-operated calcium channels could attenuate this effect.